Dissolution Process

•Influenced by:

–Free surface energy (surfactant)

–Shape of particles (surface area)

–Temperature

–Agitation (type and degree; diffusion layer)

–Amount already in solution (near saturation)

–Viscosity, volume of solvent

pH and Solubility

•To enhance stability, it may be necessary to form poorly water soluble salts:

•

–Examples

•Erythromycin stearate

•Erythromycin estolate

•Chloramphenicol palmitate

•Hydroxyzine pamoate